4nsp: Difference between revisions

<table><tr><td colspan='2'>[[4nsp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NSP FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nsp OCA], [https://pdbe.org/4nsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nsp RCSB], [https://www.ebi.ac.uk/pdbsum/4nsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nsp ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/ENDOV_HUMAN ENDOV_HUMAN] Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.<ref>PMID:23139746</ref> <ref>PMID:23912683</ref> <ref>PMID:23912718</ref>  

*[[Endonuclease 3D structures|Endonuclease 3D structures]]

[[Category: Homo sapiens]]

[[Category: Hao Z]]

[[Category: Xie W]]

[[Category: Zhang Z]]