7qns: Difference between revisions

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'''Unreleased structure'''


The entry 7qns is ON HOLD  until Paper Publication
==Peptide VYEKKP in complex with human cathepsin V C25S mutant==
 
<StructureSection load='7qns' size='340' side='right'caption='[[7qns]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
Authors: Loboda, J., Sosnowski, P., Tusar, L., Vidmar, R., Vizovisek, M., Horvat, J., Kosec, G., Impens, F., Demol, H., Turk, B., Gevaert, K., Turk, D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7qns]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QNS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QNS FirstGlance]. <br>
Description: Peptide VYEKKP in complex with human cathepsin V C25S mutant
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qns OCA], [https://pdbe.org/7qns PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qns RCSB], [https://www.ebi.ac.uk/pdbsum/7qns PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qns ProSAT]</span></td></tr>
[[Category: Demol, H]]
</table>
[[Category: Horvat, J]]
== Function ==
[[Category: Gevaert, K]]
[https://www.uniprot.org/uniprot/CATL2_HUMAN CATL2_HUMAN] Cysteine protease. May have an important role in corneal physiology.<ref>PMID:9727401</ref> <ref>PMID:10029531</ref>
[[Category: Kosec, G]]
== References ==
[[Category: Turk, B]]
<references/>
[[Category: Vizovisek, M]]
__TOC__
[[Category: Turk, D]]
</StructureSection>
[[Category: Loboda, J]]
[[Category: Homo sapiens]]
[[Category: Tusar, L]]
[[Category: Large Structures]]
[[Category: Impens, F]]
[[Category: Synthetic construct]]
[[Category: Sosnowski, P]]
[[Category: Demol H]]
[[Category: Vidmar, R]]
[[Category: Gevaert K]]
[[Category: Horvat J]]
[[Category: Impens F]]
[[Category: Kosec G]]
[[Category: Loboda J]]
[[Category: Sosnowski P]]
[[Category: Turk B]]
[[Category: Turk D]]
[[Category: Tusar L]]
[[Category: Vidmar R]]
[[Category: Vizovisek M]]

Revision as of 10:10, 18 January 2023

Peptide VYEKKP in complex with human cathepsin V C25S mutantPeptide VYEKKP in complex with human cathepsin V C25S mutant

Structural highlights

7qns is a 5 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CATL2_HUMAN Cysteine protease. May have an important role in corneal physiology.[1] [2]

References

  1. ↑ Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K. Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. Invest Ophthalmol Vis Sci. 1998 Sep;39(10):1789-96. PMID:9727401
  2. ↑ Bromme D, Li Z, Barnes M, Mehler E. Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. Biochemistry. 1999 Feb 23;38(8):2377-85. PMID:10029531 doi:10.1021/bi982175f

7qns, resolution 1.40Å

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OCA
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