Nodal signaling pathway: Difference between revisions
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<StructureSection load='4n1d' size='340' side='right' caption='Nodal/BMP2 chimera NB250' scene='90/909304/Cv/1'> | <StructureSection load='4n1d' size='340' side='right' caption='Nodal/BMP2 chimera NB250 (PDB code [[4n1d]])' scene='90/909304/Cv/1'> | ||
The Nodal signaling pathway is a signal transduction pathway important in regional and cellular differentiation during embryonic development. The Nodal family of proteins, a subset of the [[TGF beta signaling pathway#The TGF beta superfamily of ligands|transforming growth factor beta (TGFβ) superfamily]], is responsible for mesoendoderm induction, patterning of the nervous system, and determination of dorsal- ventral axis in vertebrate embryos. Activation of the Nodal pathway involves nodal binding to activin and activin-like receptors which leads to phosphorylation of the Smad2. | The Nodal signaling pathway is a signal transduction pathway important in regional and cellular differentiation during embryonic development. The Nodal family of proteins, a subset of the [[TGF beta signaling pathway#The TGF beta superfamily of ligands|transforming growth factor beta (TGFβ) superfamily]], is responsible for mesoendoderm induction, patterning of the nervous system, and determination of dorsal- ventral axis in vertebrate embryos. Activation of the Nodal pathway involves nodal binding to activin and activin-like receptors which leads to phosphorylation of the Smad2. | ||
Latest revision as of 12:51, 17 January 2023
The Nodal signaling pathway is a signal transduction pathway important in regional and cellular differentiation during embryonic development. The Nodal family of proteins, a subset of the transforming growth factor beta (TGFβ) superfamily, is responsible for mesoendoderm induction, patterning of the nervous system, and determination of dorsal- ventral axis in vertebrate embryos. Activation of the Nodal pathway involves nodal binding to activin and activin-like receptors which leads to phosphorylation of the Smad2.
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