Lysophosphatidic acid receptor: Difference between revisions
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== Introduction == | == Introduction == | ||
'''Lysophosphatidic Acid Receptor''' 1 (commonly referred to as LPA<sub>1</sub>) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA<sub>1</sub>-LPA<sub>6</sub>). These receptors bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref> LPA<sub>1</sub> is part of the larger [http://jb.oxfordjournals.org/content/131/6/767 EDG receptor family], which includes the more widely studied sphingosine 1-phosphate receptors.<ref name="regpeps"/> LPA<sub>1</sub> is responsible for initiating several different signaling cascades with different molecules and G-proteins.<ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref> These cascades ultimately result in growth, survival, and movement of cells, as well as neural cell development.<ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref> | '''Lysophosphatidic Acid Receptor''' 1 (commonly referred to as LPA<sub>1</sub>) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA<sub>1</sub>-LPA<sub>6</sub>). These receptors bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref> LPA<sub>1</sub> is part of the larger [http://jb.oxfordjournals.org/content/131/6/767 EDG receptor family], which includes the more widely studied sphingosine 1-phosphate receptors.<ref name="regpeps"/> LPA<sub>1</sub> is responsible for initiating several different signaling cascades with different molecules and G-proteins.<ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref> These cascades ultimately result in growth, survival, and movement of cells, as well as neural cell development.<ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref> | ||
See also [[Lipid signaling]]. | |||
[[Image:LPA_in_membrane4.fw.png|200px|center|thumb|'''Figure 1:''' LPA receptor (blue) bound to the cell membrane. The binding pocket is highlighted in red. The added bRIL protein is highlighted in orange.]] | [[Image:LPA_in_membrane4.fw.png|200px|center|thumb|'''Figure 1:''' LPA receptor (blue) bound to the cell membrane. The binding pocket is highlighted in red. The added bRIL protein is highlighted in orange.]] | ||