4nmh: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:


==11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one==
==11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one==
<StructureSection load='4nmh' size='340' side='right' caption='[[4nmh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='4nmh' size='340' side='right'caption='[[4nmh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nmh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NMH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nmh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NMH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2KG:(4S)-4-(2-METHOXYPHENYL)-3,3-DIMETHYL-1-[3-(METHYLSULFONYL)PHENYL]AZETIDIN-2-ONE'>2KG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2KG:(4S)-4-(2-METHOXYPHENYL)-3,3-DIMETHYL-1-[3-(METHYLSULFONYL)PHENYL]AZETIDIN-2-ONE'>2KG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hsd11b1, Hsd11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmh OCA], [https://pdbe.org/4nmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nmh RCSB], [https://www.ebi.ac.uk/pdbsum/4nmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmh ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmh OCA], [http://pdbe.org/4nmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nmh RCSB], [http://www.ebi.ac.uk/pdbsum/4nmh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.  
[https://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.


==See Also==
==See Also==
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Augustin, M]]
[[Category: Augustin M]]
[[Category: Blake, C]]
[[Category: Blake C]]
[[Category: Ertan, A]]
[[Category: Ertan A]]
[[Category: Gerhardt, S]]
[[Category: Gerhardt S]]
[[Category: Kilgour, E K]]
[[Category: Kilgour EK]]
[[Category: Krapp, S]]
[[Category: Krapp S]]
[[Category: McCoull, W]]
[[Category: McCoull W]]
[[Category: Moore, J E]]
[[Category: Moore JE]]
[[Category: Newcombe, N J]]
[[Category: Newcombe NJ]]
[[Category: Ogg, D J]]
[[Category: Ogg DJ]]
[[Category: Packer, M J]]
[[Category: Packer MJ]]
[[Category: Rees, A]]
[[Category: Rees A]]
[[Category: Revill, J]]
[[Category: Revill J]]
[[Category: Scott, J S]]
[[Category: Scott JS]]
[[Category: Selmi, N]]
[[Category: Selmi N]]
[[Category: Steinbacher, S]]
[[Category: Steinbacher S]]
[[Category: Whittamore, P R.O]]
[[Category: Whittamore PRO]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 11:34, 11 January 2023

11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one

Structural highlights

4nmh is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DHI1_MOUSE Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.

See Also

4nmh, resolution 2.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4nmh&oldid=3696964"