4ng6: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates== | ==The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates== | ||
<StructureSection load='4ng6' size='340' side='right' caption='[[4ng6]], [[Resolution|resolution]] 2.35Å' scene=''> | <StructureSection load='4ng6' size='340' side='right'caption='[[4ng6]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ng6]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ng6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NG6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ng6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ng6 OCA], [https://pdbe.org/4ng6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ng6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ng6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ng6 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
==See Also== | |||
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Barnett | [[Category: Large Structures]] | ||
[[Category: Dunford | [[Category: Barnett BL]] | ||
[[Category: Ebetino | [[Category: Dunford JE]] | ||
[[Category: Evdokimov | [[Category: Ebetino FH]] | ||
[[Category: Kavanagh | [[Category: Evdokimov A]] | ||
[[Category: Kwaasi | [[Category: Kavanagh KL]] | ||
[[Category: Muniz | [[Category: Kwaasi AA]] | ||
[[Category: Oppermann | [[Category: Muniz JRC]] | ||
[[Category: Pilka | [[Category: Oppermann U]] | ||
[[Category: Russell | [[Category: Pilka E]] | ||
[[Category: Tsoumpra | [[Category: Russell RGG]] | ||
[[Category: Walter | [[Category: Tsoumpra MK]] | ||
[[Category: Walter RL]] | |||