8edc: Difference between revisions

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'''Unreleased structure'''


The entry 8edc is ON HOLD  until Paper Publication
==Structure of C. elegans UNC-5 IG 1+2 Domains==
 
<StructureSection load='8edc' size='340' side='right'caption='[[8edc]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8edc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EDC FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8edc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8edc OCA], [https://pdbe.org/8edc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8edc RCSB], [https://www.ebi.ac.uk/pdbsum/8edc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8edc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UNC5_CAEEL UNC5_CAEEL] Receptor for netrin (unc-6) required for axon guidance (PubMed:8332188, PubMed:11454756). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:1384987, PubMed:8332188, PubMed:11454756, PubMed:9473333). Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:11454756, PubMed:9473333). Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced-10/Rac, ced-12/ELMO and mig-2/RhoG (PubMed:10631179, PubMed:26292279, PubMed:17716643).<ref>PMID:10631179</ref> <ref>PMID:11454756</ref> <ref>PMID:1384987</ref> <ref>PMID:17716643</ref> <ref>PMID:26292279</ref> <ref>PMID:8332188</ref> <ref>PMID:9473333</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Ozkan E]]
[[Category: Priest JM]]

Revision as of 10:42, 11 January 2023

Structure of C. elegans UNC-5 IG 1+2 DomainsStructure of C. elegans UNC-5 IG 1+2 Domains

Structural highlights

8edc is a 1 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UNC5_CAEEL Receptor for netrin (unc-6) required for axon guidance (PubMed:8332188, PubMed:11454756). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:1384987, PubMed:8332188, PubMed:11454756, PubMed:9473333). Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:11454756, PubMed:9473333). Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced-10/Rac, ced-12/ELMO and mig-2/RhoG (PubMed:10631179, PubMed:26292279, PubMed:17716643).[1] [2] [3] [4] [5] [6] [7]

References

  1. ↑ Su M, Merz DC, Killeen MT, Zhou Y, Zheng H, Kramer JM, Hedgecock EM, Culotti JG. Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans. Development. 2000 Feb;127(3):585-94. PMID:10631179
  2. ↑ Merz DC, Zheng H, Killeen MT, Krizus A, Culotti JG. Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo. Genetics. 2001 Jul;158(3):1071-80. PMID:11454756
  3. ↑ Leung-Hagesteijn C, Spence AM, Stern BD, Zhou Y, Su MW, Hedgecock EM, Culotti JG. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell. 1992 Oct 16;71(2):289-99. PMID:1384987
  4. ↑ Zheng H, Coudiere L, Camia C, Colavita A, Culotti JG, Merz DC. C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues. Dev Biol. 2007 Oct 1;310(1):44-53. doi: 10.1016/j.ydbio.2007.07.014. Epub 2007 , Jul 24. PMID:17716643 doi:http://dx.doi.org/10.1016/j.ydbio.2007.07.014
  5. ↑ Levy-Strumpf N, Krizus M, Zheng H, Brown L, Culotti JG. The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. PLoS Genet. 2015 Aug 20;11(8):e1005446. doi: 10.1371/journal.pgen.1005446. , eCollection 2015 Aug. PMID:26292279 doi:http://dx.doi.org/10.1371/journal.pgen.1005446
  6. ↑ Hamelin M, Zhou Y, Su MW, Scott IM, Culotti JG. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature. 1993 Jul 22;364(6435):327-30. PMID:8332188 doi:http://dx.doi.org/10.1038/364327a0
  7. ↑ Colavita A, Culotti JG. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev Biol. 1998 Feb 1;194(1):72-85. doi: 10.1006/dbio.1997.8790. PMID:9473333 doi:http://dx.doi.org/10.1006/dbio.1997.8790

8edc, resolution 2.89Å

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