7zlh: Difference between revisions
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==Cryo-EM structure of C-mannosyltransferase CeDPY19, in apo state, bound to CMT2-Fab and anti-Fab nanobody== | |||
<StructureSection load='7zlh' size='340' side='right'caption='[[7zlh]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7zlh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZLH FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zlh OCA], [https://pdbe.org/7zlh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zlh RCSB], [https://www.ebi.ac.uk/pdbsum/7zlh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zlh ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DPY19_CAEEL DPY19_CAEEL] C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right asymmetrically, QL migrates toward the posterior and QR migrates toward the anterior. Required with unc-40 to express mab-5 correctly in the Q cell descendants.<ref>PMID:11023868</ref> <ref>PMID:23562325</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caenorhabditis elegans]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Bloch JS]] | |||
[[Category: Goddard-Borger ED]] | |||
[[Category: Irobalieva R]] | |||
[[Category: Kossiakoff AA]] | |||
[[Category: Locher KP]] | |||
[[Category: Mukherjee S]] | |||