Folylpolyglutamate synthase: Difference between revisions

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	[[Folylpolyglutamate synthase]] or synthetase (FPGS) attaches gamma-glutamate units to various forms of folate (vitamin B9). In eukaryotic organisms, polyglutamylation keeps folate in the compartment, while folate lacking it can travel to other compartments. To be effective, antifolates (competitive inhibitors whose structure is similar to tetrahydrofolate) have to undergo polyglutamylation as well. Thus, defects in FPGS have consequences for the [[one-carbon metabolism]] relying on availability of folate as well as treatment of cancer relying on antifolates.		[[Folylpolyglutamate synthase]] or '''synthetase''' (FPGS) attaches gamma-glutamate units to various forms of folate (vitamin B9). In eukaryotic organisms, polyglutamylation keeps folate in the compartment, while folate lacking it can travel to other compartments. To be effective, antifolates (competitive inhibitors whose structure is similar to tetrahydrofolate) have to undergo polyglutamylation as well. Thus, defects in FPGS have consequences for the [[one-carbon metabolism]] relying on availability of folate as well as treatment of cancer relying on antifolates.

	== Function ==		== Function ==