Lactate Dehydrogenase: Difference between revisions
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'''H-lactate dehydrogenase''' (H-LDH) catalyzes the interconversion of D-lactate and ferricytochrome c to pyruvate and ferrocytochrome c.<br /> | '''H-lactate dehydrogenase''' (H-LDH) catalyzes the interconversion of D-lactate and ferricytochrome c to pyruvate and ferrocytochrome c.<br /> | ||
Lactate Dehydrogenase (LDH) is an important enzyme in humans. It occurs in different regions of the body, each region having a unique conformation of different subunits. LDH is a key enzyme in anaerobic respiration. Anaerobic Respiration is the <scene name='Lactate_Dehydrogenase/Cv/4'>conversion of pyruvate into lactate acid</scene> in the absence oxygen. This pathway is important to glycolysis in two main ways. The first is that if pyruvate were to build up glycoysis and thus the generation of ATP would slow. The second is anaerobic respiration allows for the regeneration of NAD+ from NADH. NAD+ is required when glyceraldehyde-3-phosphate dehydrogenase oxidizes glyceraldehyde-3-phosphate in glycolysis, which generates NADH. Lactate dehydrogenase is responsible for the anaerobic conversion of NADH to NAD+. <scene name='40/400612/Cv1/2'>Click here to see the residues which form interactions with pyruvate</scene> in the Lactate Dehydrogenase from ''Cryptosporidium parvum'' ([[4nd4]]). | Lactate Dehydrogenase (LDH) is an important enzyme in humans. It occurs in different regions of the body, each region having a unique conformation of different subunits. LDH is a key enzyme in anaerobic respiration. Anaerobic Respiration is the <scene name='Lactate_Dehydrogenase/Cv/4'>conversion of pyruvate into lactate acid</scene> in the absence oxygen. This pathway is important to glycolysis in two main ways. The first is that if pyruvate were to build up glycoysis and thus the generation of ATP would slow. The second is anaerobic respiration allows for the regeneration of NAD+ from NADH. NAD+ is required when glyceraldehyde-3-phosphate dehydrogenase oxidizes glyceraldehyde-3-phosphate in glycolysis, which generates NADH. Lactate dehydrogenase is responsible for the anaerobic conversion of NADH to NAD+. <scene name='40/400612/Cv1/2'>Click here to see the residues which form interactions with pyruvate</scene> in the Lactate Dehydrogenase from ''Cryptosporidium parvum'' ([[4nd4]]). | ||
See also: [[Cori cycle]]. | |||
==Human Lactate Dehydrogenase== | ==Human Lactate Dehydrogenase== | ||