Polycomb complex protein: Difference between revisions
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Proposed architecture of the PRC1 complex oligomer. | Proposed architecture of the PRC1 complex oligomer. | ||
== Disease == | == Disease == | ||
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BMI1 also inhibits the CDKN1A gene, an important inhibitor of the cellular cycle, promoting the cellular proliferation. The inhibition of CDKN1A gene is promoted when a lncRNA, FALEC (focally amplified long non-coding RNA on chromosome 1 gene), stabilizes BMI1. | BMI1 also inhibits the CDKN1A gene, an important inhibitor of the cellular cycle, promoting the cellular proliferation. The inhibition of CDKN1A gene is promoted when a lncRNA, FALEC (focally amplified long non-coding RNA on chromosome 1 gene), stabilizes BMI1. | ||
== Conservation == | == Conservation == | ||
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<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
==Polycomb complex protein== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
* Polycomb group ring finger protein 1 or Pcgf1 | |||
**[[4hpm]] – hPcgf1 167-255 + BCORL1 - human<br /> | |||
**[[4hpl]] – hPcgf1 167-255 + BCOR<br /> | |||
* BMI-1 or Polycomb group ring finger protein 4 or Pcgf4 | |||
**[[5fr6]] – hBMI1 residues 121-235 <br /> | |||
**[[2na1]] – hBMI1 residues 121-235 /polyhomeotic-like 2– NMR<br /> | |||
**[[6wi7]], [[8wi8]] – hBMI1 ring domain 1-108/Ring1B <br /> | |||
**[[7nd1]] – hBMI1 ring domain + Ring1B - NMR<br /> | |||
**[[3rpg]] – hBMI1 ring domain + Ring1B + Ubch5C<br /> | |||
**[[2ckl]] – mBMI1 ring domain + Ring1B - mouse<br /> | |||
**[[4r8p]] – BMI1 ring domain + Ring1B + Ubch5C + DNA - frog<br /> | |||
* Polycomb group ring finger protein 5 or Pcgf5 | |||
**[[4s3o]] – hPcgf5 ring domain 1-108 + Ring1B + Ubch5C<br /> | |||
* Polycomb group ring finger protein 6 or Pcgf | |||
**[[2djb]] – hPcgf6 ring domain - NMR<br /> | |||
}} | |||
</StructureSection> | </StructureSection> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
== External resources== | == External resources== | ||
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*[http://www.uniprot.org/uniprot/P35226#structure Aggregated information about BMI1 protein in UniProt database] | *[http://www.uniprot.org/uniprot/P35226#structure Aggregated information about BMI1 protein in UniProt database] | ||
*[https://www.genecards.org/cgi-bin/carddisp.pl?gene=BMI1 Aggregated information about BMI1 gene in GeneCards database] | *[https://www.genecards.org/cgi-bin/carddisp.pl?gene=BMI1 Aggregated information about BMI1 gene in GeneCards database] | ||
[[Category:Topic Page]] | |||