4mx0: Difference between revisions

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 ==Shanghai N9-peramivir==
-<StructureSection load='4mx0' size='340' side='right' caption='[[4mx0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='4mx0' size='340' side='right'caption='[[4mx0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4mx0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MX0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4mx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MX0 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCZ:3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC+ACID'>BCZ</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCZ:3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC+ACID'>BCZ</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mwj|4mwj]], [[4mwl|4mwl]], [[4mwq|4mwq]], [[4mwr|4mwr]], [[4mwu|4mwu]], [[4mwv|4mwv]], [[4mww|4mww]], [[4mwx|4mwx]], [[4mxy|4mxy]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mx0 OCA], [https://pdbe.org/4mx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mx0 RCSB], [https://www.ebi.ac.uk/pdbsum/4mx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mx0 ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 9INFA])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mx0 OCA], [http://pdbe.org/4mx0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mx0 RCSB], [http://www.ebi.ac.uk/pdbsum/4mx0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mx0 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A067Y7N7_9INFA A0A067Y7N7_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 18: @@
 </div>
 <div class="pdbe-citations 4mx0" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Gao, F]]
+[[Category: Influenza A virus]]
-[[Category: Gao, G F]]
+[[Category: Large Structures]]
-[[Category: Qi, J X]]
+[[Category: Gao F]]
-[[Category: Wu, Y]]
+[[Category: Gao GF]]
-[[Category: 6-bladed beta-propeller]]
+[[Category: Qi JX]]
-[[Category: Glycosylation]]
+[[Category: Wu Y]]
-[[Category: Hydrolase]]