4mrh: Difference between revisions

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==Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule==
==Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule==
<StructureSection load='4mrh' size='340' side='right' caption='[[4mrh]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
<StructureSection load='4mrh' size='340' side='right'caption='[[4mrh]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mrh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MRH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mrh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MRH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CQ:4-CHLORO-5-METHYLBENZENE-1,2-DIAMINE'>2CQ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CQ:4-CHLORO-5-METHYLBENZENE-1,2-DIAMINE'>2CQ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mrd|4mrd]], [[4mre|4mre]], [[4mrf|4mrf]], [[4mrg|4mrg]], [[4np2|4np2]], [[4np3|4np3]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrh OCA], [https://pdbe.org/4mrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mrh RCSB], [https://www.ebi.ac.uk/pdbsum/4mrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrh ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd44, Cd44 Ly-24, Ly-24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrh OCA], [http://pdbe.org/4mrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mrh RCSB], [http://www.ebi.ac.uk/pdbsum/4mrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE]] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.  
[https://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Finzel, B]]
[[Category: Mus musculus]]
[[Category: Liu, L K]]
[[Category: Finzel B]]
[[Category: Cell adhesion-inhibitor complex]]
[[Category: Liu LK]]
[[Category: Cell receptor]]
[[Category: Cell surface]]
[[Category: Hyaluronan binding]]
[[Category: Link module]]

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