4m7v: Difference between revisions

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==Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)and RAB-propyl==
==Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)and RAB-propyl==
<StructureSection load='4m7v' size='340' side='right' caption='[[4m7v]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4m7v' size='340' side='right'caption='[[4m7v]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4m7v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M7V FirstGlance]. <br>
<table><tr><td colspan='2'>[[4m7v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M7V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=RAR:5-(3,4-DIMETHOXY-5-{(1E)-3-OXO-3-[(1S)-1-PROPYLPHTHALAZIN-2(1H)-YL]PROP-1-EN-1-YL}BENZYL)PYRIMIDINE-2,4-DIAMINE'>RAR</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=RAR:5-(3,4-DIMETHOXY-5-{(1E)-3-OXO-3-[(1S)-1-PROPYLPHTHALAZIN-2(1H)-YL]PROP-1-EN-1-YL}BENZYL)PYRIMIDINE-2,4-DIAMINE'>RAR</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m7u|4m7u]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7v OCA], [https://pdbe.org/4m7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m7v RCSB], [https://www.ebi.ac.uk/pdbsum/4m7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m7v ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dihydrofolate reductase, EF_1577, folA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7v OCA], [http://pdbe.org/4m7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m7v RCSB], [http://www.ebi.ac.uk/pdbsum/4m7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m7v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q834R2_ENTFA Q834R2_ENTFA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]  
[https://www.uniprot.org/uniprot/Q834R2_ENTFA Q834R2_ENTFA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
<div class="pdbe-citations 4m7v" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4m7v" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydrofolate reductase]]
[[Category: Enterococcus faecalis V583]]
[[Category: Entfa]]
[[Category: Large Structures]]
[[Category: Bourne, C R]]
[[Category: Bourne CR]]
[[Category: Oxidoreductase]]
[[Category: Reduction of dihydrofolate to tetrahydrofolate]]

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