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==Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)== | ==Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)== | ||
<StructureSection load='4lva' size='340' side='right' caption='[[4lva]], [[Resolution|resolution]] 1.55Å' scene=''> | <StructureSection load='4lva' size='340' side='right'caption='[[4lva]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lva]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4lva]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVA FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=20M:N-(4-{[4-(PYRROLIDIN-1-YL)PIPERIDIN-1-YL]SULFONYL}BENZYL)-2H-PYRIDO[4,3-E][1,2,4]THIADIAZIN-3-AMINE+1,1-DIOXIDE'>20M</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=20M:N-(4-{[4-(PYRROLIDIN-1-YL)PIPERIDIN-1-YL]SULFONYL}BENZYL)-2H-PYRIDO[4,3-E][1,2,4]THIADIAZIN-3-AMINE+1,1-DIOXIDE'>20M</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lva OCA], [https://pdbe.org/4lva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lva RCSB], [https://www.ebi.ac.uk/pdbsum/4lva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lva ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 21: | Line 18: | ||
</div> | </div> | ||
<div class="pdbe-citations 4lva" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4lva" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bravo | [[Category: Bravo B]] | ||
[[Category: Dragovich PS]] | |||
[[Category: Dragovich | [[Category: Feng Y]] | ||
[[Category: Feng | [[Category: Giannetti AM]] | ||
[[Category: Giannetti | [[Category: Gunzner-Toste J]] | ||
[[Category: Gunzner-Toste | [[Category: Ho Y]] | ||
[[Category: Ho | [[Category: Hua R]] | ||
[[Category: Hua | [[Category: Liederer BM]] | ||
[[Category: Liederer | [[Category: Liu Y]] | ||
[[Category: Liu | [[Category: O'Brien T]] | ||
[[Category: Oeh | [[Category: Oeh J]] | ||
[[Category: Sampath | [[Category: Sampath D]] | ||
[[Category: Shen | [[Category: Shen Y]] | ||
[[Category: Skelton | [[Category: Skelton N]] | ||
[[Category: Wang | [[Category: Wang C]] | ||
[[Category: Wang | [[Category: Wang L]] | ||
[[Category: Wang | [[Category: Wang W]] | ||
[[Category: Wu | [[Category: Wu H]] | ||
[[Category: Xiao | [[Category: Xiao Y]] | ||
[[Category: Yuen | [[Category: Yuen P]] | ||
[[Category: Zak | [[Category: Zak M]] | ||
[[Category: Zhao | [[Category: Zhao G]] | ||
[[Category: Zhao | [[Category: Zhao Q]] | ||
[[Category: Zheng | [[Category: Zheng X]] | ||