4ltb: Difference between revisions

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OCA

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 <StructureSection load='4ltb' size='340' side='right'caption='[[4ltb]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ltb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LTB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ltb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LTB FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ltb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ltb OCA], [http://pdbe.org/4ltb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ltb RCSB], [http://www.ebi.ac.uk/pdbsum/4ltb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ltb ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ltb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ltb OCA], [https://pdbe.org/4ltb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ltb RCSB], [https://www.ebi.ac.uk/pdbsum/4ltb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ltb ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 19: @@
 ==See Also==
-*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Okreglicka, K]]
+[[Category: Okreglicka K]]
-[[Category: Pornillos, O]]
+[[Category: Pornillos O]]
-[[Category: Sanchez, J G]]
+[[Category: Sanchez JG]]
-[[Category: Coiled-coil]]
-[[Category: Metal binding protein]]