6g9e: Difference between revisions
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<StructureSection load='6g9e' size='340' side='right'caption='[[6g9e]], [[Resolution|resolution]] 2.69Å' scene=''> | <StructureSection load='6g9e' size='340' side='right'caption='[[6g9e]], [[Resolution|resolution]] 2.69Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6g9e]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G9E OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6g9e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichuris_suis Trichuris suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G9E FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g9e OCA], [https://pdbe.org/6g9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g9e RCSB], [https://www.ebi.ac.uk/pdbsum/6g9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g9e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A085LU44_9BILA A0A085LU44_9BILA] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Immunomodulation of airway hyperreactivity by excretory-secretory (ES) products of the first larval stage (L1) of the gastrointestinal nematode Trichuris suis is reported by us and others. Here, we aimed to identify the proteins accounting for the modulatory effects of the T. suis L1 ES proteins and studied six selected T. suis L1 proteins for their immunomodulatory efficacy in a murine OVA-induced allergic airway disease model. In particular, an enzymatically active T. suis chitinase mediated amelioration of clinical signs of airway hyperreactivity, primarily associated with suppression of eosinophil recruitment into the lung, the associated chemokines, and increased numbers of RELMalpha (+) interstitial lung macrophages. While there is no indication of T. suis chitinase directly interfering with dendritic cell activation or antigen presentation to CD4 T cells, treatment of allergic mice with the worm chitinase influenced the hosts' own chitinase activity in the inflamed lung. The three-dimensional structure of the T. suis chitinase as determined by high-resolution X-ray crystallography revealed high similarities to mouse acidic mammalian chitinase (AMCase) but a unique ability of T. suis chitinase to form dimers. Our data indicate that the structural similarities between the parasite and host chitinase contribute to the disease-ameliorating effect of the helminth-derived chitinase on allergic lung inflammation. | |||
A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease.,Ebner F, Lindner K, Janek K, Niewienda A, Malecki PH, Weiss MS, Sutherland TE, Heuser A, Kuhl AA, Zentek J, Hofmann A, Hartmann S J Immunol Res. 2021 Nov 25;2021:6234836. doi: 10.1155/2021/6234836. eCollection , 2021. PMID:34869783<ref>PMID:34869783</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6g9e" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Chitinase 3D structures|Chitinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Balster | [[Category: Trichuris suis]] | ||
[[Category: Hartmann | [[Category: Balster K]] | ||
[[Category: Heinemann | [[Category: Hartmann S]] | ||
[[Category: Malecki | [[Category: Heinemann U]] | ||
[[Category: Weiss | [[Category: Malecki PH]] | ||
[[Category: Weiss MS]] | |||