8bw2: Difference between revisions

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-'''Unreleased structure'''
-The entry 8bw2 is ON HOLD
+==PanDDA analysis -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative==
+<StructureSection load='8bw2' size='340' side='right'caption='[[8bw2]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
-Authors: Grosjean, H., Aimon, A., Hassell-Hart, S., Bradshaw, W.J., Krojer, T., Talon, R., Douangamath, A., Koekemoer, L., Biggin, P.C., Spencer, J., von Delft, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8bw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5s9f 5s9f]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BW2 FirstGlance]. <br>
-Description: PanDDA analysis --Crystal Structure of PHIP in complex with Z198194396 synthetic derivative
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y3Y:(2R)-N-(2-methoxyethyl)-2-methyl-4-thiophen-2-ylcarbonyl-piperazine-1-carboxamide'>Y3Y</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bw2 OCA], [https://pdbe.org/8bw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bw2 RCSB], [https://www.ebi.ac.uk/pdbsum/8bw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bw2 ProSAT]</span></td></tr>
-[[Category: Spencer, J]]
+</table>
-[[Category: Aimon, A]]
+== Function ==
-[[Category: Grosjean, H]]
+[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref>
-[[Category: Biggin, P.C]]
+== References ==
-[[Category: Bradshaw, W.J]]
+<references/>
-[[Category: Hassell-Hart, S]]
+__TOC__
-[[Category: Von Delft, F]]
+</StructureSection>
-[[Category: Koekemoer, L]]
+[[Category: Homo sapiens]]
-[[Category: Talon, R]]
+[[Category: Large Structures]]
-[[Category: Douangamath, A]]
+[[Category: Aimon A]]
-[[Category: Krojer, T]]
+[[Category: Biggin PC]]
+[[Category: Bradshaw WJ]]
+[[Category: Douangamath A]]
+[[Category: Grosjean H]]
+[[Category: Hassell-Hart S]]
+[[Category: Koekemoer L]]
+[[Category: Krojer T]]
+[[Category: Spencer J]]
+[[Category: Talon R]]
+[[Category: Von Delft F]]