Glycolysis Enzymes: Difference between revisions
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The first phase of glycolysis is sometimes referred to as the "investment phase", where ATP is consumed to set up later, energy generating steps. | The first phase of glycolysis is sometimes referred to as the "investment phase", where ATP is consumed to set up later, energy generating steps. | ||
The first step of the pathway is the conversion of <scene name=' | The first step of the pathway is the conversion of <scene name='94/942621/Cv/4'>glucose</scene> to <scene name='94/942621/Cv/5'>glucose-6-phosphate</scene> by either hexokinase or glucokinase. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. All hexokinases are capable of phosphorylating several hexoses but glucokinase acts with a 50-fold lower substrate affinity and its main hexose substrate is glucose.[https://en.wikipedia.org/wiki/Hexokinase] | ||
'''Step 2: Phosphoglucose isomerase''' | '''Step 2: Phosphoglucose isomerase''' | ||
<scene name=' | <scene name='94/942621/Cv/5'>Glucose-6-phosphate</scene> isomerizes to <scene name='39/392339/Cv1/1'>fructose-6-phosphate</scene>; this reaction is catalyzed by [[Stancu_Phosphoglucoisomerase_Sandbox_1|phosphoglucoisomerase]]. This isomerization allows for the creation of two, three carbon sugars as a product. | ||
*[[Phosphoglucose isomerase]] | *[[Phosphoglucose isomerase]] | ||
Rabbit <scene name='48/481605/Cv/6'>PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit</scene><ref>PMID:11425306</ref>. Water molecules are shown as red spheres. | Rabbit <scene name='48/481605/Cv/6'>PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit</scene><ref>PMID:11425306</ref>. Water molecules are shown as red spheres. | ||