4lg8: Difference between revisions

<StructureSection load='4lg8' size='340' side='right'caption='[[4lg8]], [[Resolution|resolution]] 1.89&Aring;' scene=''>

<table><tr><td colspan='2'>[[4lg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LG8 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg8 OCA], [https://pdbe.org/4lg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lg8 RCSB], [https://www.ebi.ac.uk/pdbsum/4lg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lg8 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PRP19_HUMAN PRP19_HUMAN] Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.<ref>PMID:11082287</ref> <ref>PMID:12960389</ref> <ref>PMID:16332694</ref> <ref>PMID:15660529</ref> <ref>PMID:16223718</ref> <ref>PMID:16388800</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Dobrovetsky E]]

[[Category: Edwards AM]]

[[Category: He H]]

[[Category: Min J]]

[[Category: Seitova A]]

[[Category: Tempel W]]

[[Category: Xu C]]