4l9u: Difference between revisions

<StructureSection load='4l9u' size='340' side='right'caption='[[4l9u]], [[Resolution|resolution]] 1.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[4l9u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9U FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9u OCA], [https://pdbe.org/4l9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9u RCSB], [https://www.ebi.ac.uk/pdbsum/4l9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9u ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.

[https://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN] Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation.<ref>PMID:10807788</ref> <ref>PMID:12839994</ref> <ref>PMID:12782630</ref> <ref>PMID:12845332</ref> <ref>PMID:15060167</ref> <ref>PMID:15184873</ref> <ref>PMID:15899849</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Barros T]]

[[Category: Che Y]]

[[Category: Das R]]

[[Category: Iwig JS]]

[[Category: Kuriyan J]]

[[Category: Limnander A]]

[[Category: Pelton JG]]

[[Category: Roose JP]]

[[Category: Vercoulen Y]]

[[Category: Wemmer DE]]