7zr5: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 7zr5 is ON HOLD  until sometime in the future
==CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex==
 
<StructureSection load='7zr5' size='340' side='right'caption='[[7zr5]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
Authors: Oberoi, J., Pearl, L.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7zr5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZR5 FirstGlance]. <br>
Description: CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zr5 OCA], [https://pdbe.org/7zr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zr5 RCSB], [https://www.ebi.ac.uk/pdbsum/7zr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zr5 ProSAT]</span></td></tr>
[[Category: Oberoi, J]]
</table>
[[Category: Pearl, L.H]]
== Function ==
[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Oberoi J]]
[[Category: Pearl LH]]

Revision as of 13:07, 14 December 2022

CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complexCryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex

Structural highlights

7zr5 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HS90B_HUMAN Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.[1] [2]

References

  1. ↑ Chadli A, Graham JD, Abel MG, Jackson TA, Gordon DF, Wood WM, Felts SJ, Horwitz KB, Toft D. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol Cell Biol. 2006 Mar;26(5):1722-30. PMID:16478993 doi:http://dx.doi.org/26/5/1722
  2. ↑ Retzlaff M, Stahl M, Eberl HC, Lagleder S, Beck J, Kessler H, Buchner J. Hsp90 is regulated by a switch point in the C-terminal domain. EMBO Rep. 2009 Oct;10(10):1147-53. Epub 2009 Aug 21. PMID:19696785 doi:http://dx.doi.org/embor2009153

7zr5, resolution 3.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=7zr5&oldid=3681426"