4l5z: Difference between revisions

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==Crystal structure of the Candida albicans Methionine Synthase in complex with Homocysteine==
==Crystal structure of the Candida albicans Methionine Synthase in complex with Homocysteine==
<StructureSection load='4l5z' size='340' side='right' caption='[[4l5z]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
<StructureSection load='4l5z' size='340' side='right'caption='[[4l5z]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L5Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[4l5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HCS:2-AMINO-4-MERCAPTO-BUTYRIC+ACID'>HCS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HCS:2-AMINO-4-MERCAPTO-BUTYRIC+ACID'>HCS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l61|4l61]], [[4l64|4l64]], [[4l65|4l65]], [[4l6h|4l6h]], [[4l6o|4l6o]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5z OCA], [https://pdbe.org/4l5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5z RCSB], [https://www.ebi.ac.uk/pdbsum/4l5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5z ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5z OCA], [http://pdbe.org/4l5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l5z RCSB], [http://www.ebi.ac.uk/pdbsum/4l5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/METE_CANAL METE_CANAL]] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]  
[https://www.uniprot.org/uniprot/METE_CANAL METE_CANAL] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]
[[Category: Candida albicans SC5314]]
[[Category: Canal]]
[[Category: Large Structures]]
[[Category: Robertus, J D]]
[[Category: Robertus JD]]
[[Category: Ubhi, D]]
[[Category: Ubhi D]]
[[Category: Cobalamin-independent]]
[[Category: Dual tim barrel]]
[[Category: Fungal]]
[[Category: Methionine synthase]]
[[Category: Surface entropy reduction]]
[[Category: Transferase]]

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