4l5n: Difference between revisions

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==Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56==
==Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56==
<StructureSection load='4l5n' size='340' side='right' caption='[[4l5n]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
<StructureSection load='4l5n' size='340' side='right'caption='[[4l5n]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l5n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bppza Bppza] and [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L5N FirstGlance]. <br>
<table><tr><td colspan='2'>[[4l5n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_PZA Bacillus phage PZA] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1]), 1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10757 BPPZA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5n OCA], [https://pdbe.org/4l5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5n RCSB], [https://www.ebi.ac.uk/pdbsum/4l5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5n ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5n OCA], [http://pdbe.org/4l5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l5n RCSB], [http://www.ebi.ac.uk/pdbsum/4l5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref>
[https://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[DNA glycosylase|DNA glycosylase]]
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
*[[Uracil-DNA glycosylase|Uracil-DNA glycosylase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bppza]]
[[Category: Bacillus phage PZA]]
[[Category: Hhv-1]]
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Uracil-DNA glycosylase]]
[[Category: Large Structures]]
[[Category: Baltulionis, G]]
[[Category: Baltulionis G]]
[[Category: Cole, A R]]
[[Category: Cole AR]]
[[Category: Hornyak, P]]
[[Category: Hornyak P]]
[[Category: Ryzhenkova, K]]
[[Category: Ryzhenkova K]]
[[Category: Sapir, O]]
[[Category: Sapir O]]
[[Category: Savva, R]]
[[Category: Savva R]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Udg inhibition]]

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