8b9f: Difference between revisions

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'''Unreleased structure'''


The entry 8b9f is ON HOLD
==Structure of Echovirus 11 complexed with DAF (CD55) calculated from symmetry expansion==
 
<StructureSection load='8b9f' size='340' side='right'caption='[[8b9f]], [[Resolution|resolution]] 3.93&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8b9f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Echovirus_E11 Echovirus E11] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B9F FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b9f OCA], [https://pdbe.org/8b9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b9f RCSB], [https://www.ebi.ac.uk/pdbsum/8b9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b9f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Echovirus E11]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Qin L]]
[[Category: Ren J]]
[[Category: Stuart DI]]
[[Category: Zhou D]]

Revision as of 11:18, 7 December 2022

Structure of Echovirus 11 complexed with DAF (CD55) calculated from symmetry expansionStructure of Echovirus 11 complexed with DAF (CD55) calculated from symmetry expansion

Structural highlights

8b9f is a 4 chain structure with sequence from Echovirus E11 and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DAF_HUMAN This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.[1]

References

  1. ↑ Ward T, Pipkin PA, Clarkson NA, Stone DM, Minor PD, Almond JW. Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method. EMBO J. 1994 Nov 1;13(21):5070-4. PMID:7525274

8b9f, resolution 3.93Å

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OCA
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