1j90: Difference between revisions

Revision as of 20:56, 2 May 2008

Crystal Structure of Drosophila Deoxyribonucleoside Kinase

OverviewOverview

Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides and activate a number of medically important nucleoside analogs. Here we report the structure of the Drosophila deoxyribonucleoside kinase with deoxycytidine bound at the nucleoside binding site and that of the human deoxyguanosine kinase with ATP at the nucleoside substrate binding site. Compared to the human kinase, the Drosophila kinase has a wider substrate cleft, which may be responsible for the broad substrate specificity of this enzyme. The human deoxyguanosine kinase is highly specific for purine substrates; this is apparently due to the presence of Arg 118, which provides favorable hydrogen bonding interactions with the substrate. The two new structures provide an explanation for the substrate specificity of cellular deoxyribonucleoside kinases.

About this StructureAbout this Structure

1J90 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for substrate specificities of cellular deoxyribonucleoside kinases., Johansson K, Ramaswamy S, Ljungcrantz C, Knecht W, Piskur J, Munch-Petersen B, Eriksson S, Eklund H, Nat Struct Biol. 2001 Jul;8(7):616-20. PMID:11427893 Page seeded by OCA on Fri May 2 20:55:58 2008

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OCA

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 '''Crystal Structure of Drosophila Deoxyribonucleoside Kinase'''
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 [[Category: Piskur, J.]]
 [[Category: Ramaswamy, S.]]
-[[Category: protein-deoxynucleoside complex]]
+[[Category: Protein-deoxynucleoside complex]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:55:58 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:30:17 2008''