Gluconeogenesis: Difference between revisions
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Gluconeogenesis is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. In humans the main gluconeogenic precursors are lactate, <scene name='92/925544/Cv/1'>glycerol</scene> (which is a part of the triglyceride molecule), alanine and glutamine. Other glucogenic amino acids and all [[Citric Acid Cycle]] intermediates (through conversion to oxaloacetate) can also function as substrates for gluconeogenesis. | [https://en.wikipedia.org/wiki/Gluconeogenesis|Gluconeogenesis] is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. In humans the main gluconeogenic precursors are lactate, <scene name='92/925544/Cv/1'>glycerol</scene> (which is a part of the triglyceride molecule), alanine and glutamine. Other glucogenic amino acids and all [[Citric Acid Cycle]] intermediates (through conversion to oxaloacetate) can also function as substrates for gluconeogenesis. | ||
<scene name='39/392339/Cv1/10'>Lactate</scene> is transported back to the liver where it is converted into <scene name='39/392339/Cv1/11'>pyruvate</scene> by the [[Cori cycle]] using the enzyme [[lactate dehydrogenase]]. <scene name='Lactate_Dehydrogenase/Cv/4'>Interconversion of pyruvate and lactate acid</scene>. Pyruvate, the first designated substrate of the gluconeogenic pathway, can then be used to generate glucose. | <scene name='39/392339/Cv1/10'>Lactate</scene> is transported back to the liver where it is converted into <scene name='39/392339/Cv1/11'>pyruvate</scene> by the [[Cori cycle]] using the enzyme [[lactate dehydrogenase]]. <scene name='Lactate_Dehydrogenase/Cv/4'>Interconversion of pyruvate and lactate acid</scene>. Pyruvate, the first designated substrate of the gluconeogenic pathway, can then be used to generate glucose. | ||