8e1j: Difference between revisions

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'''Unreleased structure'''


The entry 8e1j is ON HOLD  until Paper Publication
==Asp1 kinase in complex with 1,5-IP8==
 
<StructureSection load='8e1j' size='340' side='right'caption='[[8e1j]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Goldgur, Y., Shuman, S., Benjamin, B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8e1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E1J FirstGlance]. <br>
Description: Asp1 kinase in complex with 1,5-IP8
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I8P:(1R,3S,4R,5S,6R)-2,4,5,6-TETRAKIS(PHOSPHONOOXY)CYCLOHEXANE-1,3-DIYL+BIS[TRIHYDROGEN+(DIPHOSPHATE)]'>I8P</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e1j OCA], [https://pdbe.org/8e1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e1j RCSB], [https://www.ebi.ac.uk/pdbsum/8e1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e1j ProSAT]</span></td></tr>
[[Category: Benjamin, B]]
</table>
[[Category: Goldgur, Y]]
== Function ==
[[Category: Shuman, S]]
[https://www.uniprot.org/uniprot/VIP1_SCHPO VIP1_SCHPO] Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (By similarity). Required for maintaining cellular integrity, normal growth and interactions with the ARP complex (PubMed:10388810). Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability (By similarity). Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth (PubMed:10388810). Regulates polarized growth and modulates interphase microtubule cytoskeleton. Regulates microtubule dynamics without the requirement of microtubule plus-end tracking protein Mal3. Required for growth zone selection (PubMed:25254656).[UniProtKB:O43314][UniProtKB:Q06685]<ref>PMID:10388810</ref> <ref>PMID:25254656</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Benjamin B]]
[[Category: Goldgur Y]]
[[Category: Shuman S]]

Revision as of 13:46, 30 November 2022

Asp1 kinase in complex with 1,5-IP8Asp1 kinase in complex with 1,5-IP8

Structural highlights

8e1j is a 2 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VIP1_SCHPO Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (By similarity). Required for maintaining cellular integrity, normal growth and interactions with the ARP complex (PubMed:10388810). Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability (By similarity). Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth (PubMed:10388810). Regulates polarized growth and modulates interphase microtubule cytoskeleton. Regulates microtubule dynamics without the requirement of microtubule plus-end tracking protein Mal3. Required for growth zone selection (PubMed:25254656).[UniProtKB:O43314][UniProtKB:Q06685][1] [2]

References

  1. ↑ Feoktistova A, McCollum D, Ohi R, Gould KL. Identification and characterization of Schizosaccharomyces pombe asp1(+), a gene that interacts with mutations in the Arp2/3 complex and actin. Genetics. 1999 Jul;152(3):895-908. doi: 10.1093/genetics/152.3.895. PMID:10388810 doi:http://dx.doi.org/10.1093/genetics/152.3.895
  2. ↑ Pohlmann J, Risse C, Seidel C, Pohlmann T, Jakopec V, Walla E, Ramrath P, Takeshita N, Baumann S, Feldbrugge M, Fischer R, Fleig U. The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. PLoS Genet. 2014 Sep 25;10(9):e1004586. doi: 10.1371/journal.pgen.1004586. , eCollection 2014 Sep. PMID:25254656 doi:http://dx.doi.org/10.1371/journal.pgen.1004586

8e1j, resolution 1.60Å

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