Gluconeogenesis: Difference between revisions

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[by [[Phosphoenolpyruvate carboxykinase]]] <scene name='39/392339/Cv1/8'>phosphoenolpyruvate</scene> (PEP) => ... => <scene name='39/392339/Cv/3'>Glucose</scene>
[by [[Phosphoenolpyruvate carboxykinase]]] <scene name='39/392339/Cv1/8'>phosphoenolpyruvate</scene> (PEP) => ... => <scene name='39/392339/Cv/3'>Glucose</scene>


he location of the enzyme that links these two parts of gluconeogenesis by converting oxaloacetate to PEP – [[PEP carboxykinase]] (PEPCK) – is variable by species: it can be found entirely within the mitochondria, entirely within the cytosol, or dispersed evenly between the two, as it is in humans.
The location of the enzyme that links these two parts of gluconeogenesis by converting oxaloacetate to PEP – [[PEP carboxykinase]] (PEPCK) – is variable by species: it can be found entirely within the mitochondria, entirely within the cytosol, or dispersed evenly between the two, as it is in humans. ''E. coli'' GTP-driven PEPCK <scene name='54/540171/Cv/9'>active site</scene> is located in a pocket at the enzyme surface<ref>PMID:11851336</ref>. Water molecules are shown as red spheres.


'''Fatty acids'''
'''Fatty acids'''

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Alexander Berchansky