Gluconeogenesis: Difference between revisions
No edit summary |
No edit summary |
||
Line 27: | Line 27: | ||
[by [[Phosphoenolpyruvate carboxykinase]]] <scene name='39/392339/Cv1/8'>phosphoenolpyruvate</scene> (PEP) => ... => <scene name='39/392339/Cv/3'>Glucose</scene> | [by [[Phosphoenolpyruvate carboxykinase]]] <scene name='39/392339/Cv1/8'>phosphoenolpyruvate</scene> (PEP) => ... => <scene name='39/392339/Cv/3'>Glucose</scene> | ||
The location of the enzyme that links these two parts of gluconeogenesis by converting oxaloacetate to PEP – [[PEP carboxykinase]] (PEPCK) – is variable by species: it can be found entirely within the mitochondria, entirely within the cytosol, or dispersed evenly between the two, as it is in humans. ''E. coli'' GTP-driven PEPCK <scene name='54/540171/Cv/9'>active site</scene> is located in a pocket at the enzyme surface<ref>PMID:11851336</ref>. Water molecules are shown as red spheres. | |||
'''Fatty acids''' | '''Fatty acids''' |