7frt: Difference between revisions

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-'''Unreleased structure'''
-The entry 7frt is ON HOLD
+==PanDDA analysis group deposition of ground-state model of PTP1B, using pre-clustering, cluster 1==
+<StructureSection load='7frt' size='340' side='right'caption='[[7frt]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
-Authors: Mehlman, T., Biel, J., Azeem, S.M., Nelson, E.R., Hossain, S., Dunnett, L.E., Paterson, N.G., Douangamath, A., Talon, R., Axford, D., Orins, H., von Delft, F., Keedy, D.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7frt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FRT FirstGlance]. <br>
-Description: PanDDA analysis group deposition of ground-state model of PTP1B, using pre-clustering, cluster 1
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7frt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7frt OCA], [https://pdbe.org/7frt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7frt RCSB], [https://www.ebi.ac.uk/pdbsum/7frt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7frt ProSAT]</span></td></tr>
-[[Category: Mehlman, T]]
+</table>
-[[Category: Biel, J]]
+== Function ==
-[[Category: Nelson, E.R]]
+[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
-[[Category: Azeem, S.M]]
+== References ==
-[[Category: Paterson, N.G]]
+<references/>
-[[Category: Dunnett, L.E]]
+__TOC__
-[[Category: Talon, R]]
+</StructureSection>
-[[Category: Keedy, D.A]]
+[[Category: Homo sapiens]]
-[[Category: Douangamath, A]]
+[[Category: Large Structures]]
-[[Category: Hossain, S]]
+[[Category: Axford D]]
-[[Category: Orins, H]]
+[[Category: Azeem SM]]
-[[Category: Von Delft, F]]
+[[Category: Biel J]]
-[[Category: Axford, D]]
+[[Category: Douangamath A]]
+[[Category: Dunnett LE]]
+[[Category: Hossain S]]
+[[Category: Keedy DA]]
+[[Category: Mehlman T]]
+[[Category: Nelson ER]]
+[[Category: Orins H]]
+[[Category: Paterson NG]]
+[[Category: Talon R]]
+[[Category: Von Delft F]]