Circadian clock protein: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'> | ||
'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]]. | '''Circadian clock proteins''' or '''Circadian clock protein kinase''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]]. | ||
Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]). | Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]). | ||
Revision as of 11:26, 24 November 2022
Circadian clock proteins or Circadian clock protein kinase measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA[1] stimulates KaiC[2] which adds phosphate groups to itself. Then KaiC binds to KaiB[3] which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.[4] For details of KaiC see Circadian Clock Protein KaiC. Circadian clock protein KaiA from Synechococcus elongatus is (PDB entry 1r8j). 3D Structures of circadian clock proteinCircadian clock protein 3D structures
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ReferencesReferences
- ↑ Ye S, Vakonakis I, Ioerger TR, LiWang AC, Sacchettini JC. Crystal structure of circadian clock protein KaiA from Synechococcus elongatus. J Biol Chem. 2004 May 7;279(19):20511-8. Epub 2004 Mar 8. PMID:15007067 doi:10.1074/jbc.M400077200
- ↑ Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M. Visualizing a circadian clock protein: crystal structure of KaiC and functional insights. Mol Cell. 2004 Aug 13;15(3):375-88. PMID:15304218 doi:10.1016/j.molcel.2004.07.013
- ↑ . PMID:15716247
- ↑ Harmer SL, Panda S, Kay SA. Molecular bases of circadian rhythms. Annu Rev Cell Dev Biol. 2001;17:215-53. PMID:11687489 doi:http://dx.doi.org/10.1146/annurev.cellbio.17.1.215