Gluconeogenesis: Difference between revisions

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1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP
1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP
Like all kinases it is a transferase. PGK is a major enzyme used in glycolysis, in the first ATP-generating step of the glycolytic pathway. In '''gluconeogenesis''', the reaction catalyzed by PGK proceeds in the opposite direction, generating ADP and 3-phosphoglycerate (3-PG)
Like all kinases it is a transferase. PGK is a major enzyme used in glycolysis, in the first ATP-generating step of the glycolytic pathway. In gluconeogenesis, the reaction catalyzed by PGK proceeds in the opposite direction, generating ADP and 3-phosphoglycerate (3-PG)


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== References ==
== References ==
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Revision as of 16:04, 22 November 2022

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Gluconeogenesis is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. Phosphoglycerate kinase is an enzyme that catalyzes the reversible transfer of a phosphate group from to ADP producing and ATP:

1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP

Like all kinases it is a transferase. PGK is a major enzyme used in glycolysis, in the first ATP-generating step of the glycolytic pathway. In gluconeogenesis, the reaction catalyzed by PGK proceeds in the opposite direction, generating ADP and 3-phosphoglycerate (3-PG)


Human phosphoglycerate kinase complex with phosphoglyceric acid, ADP (stick model) AlF4-, Cl- and Mg+2 ions (green) (PDB code 2y3i)

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ReferencesReferences

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