4ix7: Difference between revisions

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OCA

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 ==Crystal Structure of the insv-BEN domain complexed to its DNA target site==
-<StructureSection load='4ix7' size='340' side='right' caption='[[4ix7]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
+<StructureSection load='4ix7' size='340' side='right'caption='[[4ix7]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ix7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IX7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ix7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IX7 FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG3227, insensitive, insv ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ix7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ix7 OCA], [https://pdbe.org/4ix7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ix7 RCSB], [https://www.ebi.ac.uk/pdbsum/4ix7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ix7 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ix7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ix7 OCA], [http://pdbe.org/4ix7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ix7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ix7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ix7 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/INSV_DROME INSV_DROME] Can act as both a transcriptional repressor and corepressor. Represses the expression of genes involved in neural development and preferentially binds palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression (PubMed:25561495, PubMed:23468431). Acts as a corepressor for suppressor of hairless (Su(H)) and inhibits Notch signaling during peripheral nervous system development (PubMed:21765394, PubMed:25561495).<ref>PMID:21765394</ref> <ref>PMID:23468431</ref> <ref>PMID:25561495</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Drome]]
+[[Category: Drosophila melanogaster]]
-[[Category: Patel, D J]]
+[[Category: Large Structures]]
-[[Category: Ren, A]]
+[[Category: Patel DJ]]
-[[Category: Serganov, A]]
+[[Category: Ren A]]
-[[Category: Ben domain]]
+[[Category: Serganov A]]
-[[Category: Dna binding protein-dna complex]]
-[[Category: Transcriptional repressor]]