4iup: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==crystal structure of Se-substituted arabidopsis thaliana SHH1 SAWADEE domain L200M/L218M mutant==
-<StructureSection load='4iup' size='340' side='right' caption='[[4iup]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='4iup' size='340' side='right'caption='[[4iup]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4iup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IUP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4iup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IUP FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CVM:CYMAL-4'>CVM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CVM:CYMAL-4'>CVM</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iup OCA], [https://pdbe.org/4iup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iup RCSB], [https://www.ebi.ac.uk/pdbsum/4iup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iup ProSAT]</span></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4iuq|4iuq]], [[4iur|4iur]], [[4iut|4iut]], [[4iuu|4iuu]], [[4iuv|4iuv]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">F9L1.16, At1g15215, AT1G15215 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iup OCA], [http://pdbe.org/4iup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iup RCSB], [http://www.ebi.ac.uk/pdbsum/4iup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iup ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/SHH1_ARATH SHH1_ARATH] Involved in RNA-directed DNA methylation (RdDM). Required for the silencing of some endogenous RdDM targets and accumulation of 24-nt siRNAs, but not for the production of Pol V-dependent transcripts. Functions in transcriptional silencing through both DNA methylation-dependent and -independent pathways. Required for both maintenance and de-novo DNA methylation. Plays a role in the recruitment of Pol IV to genomic regions associated with K9 methylated histone H3 that are targets for RdDM.<ref>PMID:21811420</ref> <ref>PMID:22064704</ref> <ref>PMID:23636332</ref> <ref>PMID:23637343</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Arath]]
+[[Category: Arabidopsis thaliana]]
-[[Category: Du, J]]
+[[Category: Large Structures]]
-[[Category: Patel, D J]]
+[[Category: Du J]]
-[[Category: Dna binding protein]]
+[[Category: Patel DJ]]
-[[Category: Gene regulation]]
-[[Category: Histone]]
-[[Category: Mediate interaction]]
-[[Category: Tandem tudor]]
-[[Category: Zinc finger]]