4is8: Difference between revisions

<StructureSection load='4is8' size='340' side='right' caption='[[4is8]], [[Resolution|resolution]] 2.78&Aring;' scene=''>

<table><tr><td colspan='2'>[[4is8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IS8 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B1F, CPF, FTF, NR5A2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4is8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4is8 OCA], [http://pdbe.org/4is8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4is8 RCSB], [http://www.ebi.ac.uk/pdbsum/4is8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4is8 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.  

[[Category: Human]]

[[Category: Musille, P M]]

[[Category: Ortlund, E A]]

[[Category: Pathak, M C]]

[[Category: Ligand binding domain]]

[[Category: Transcription]]