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==Crystal structure of Staphylococcus aureus ClpP in complex with ZG180== | |||
<StructureSection load='7wid' size='340' side='right'caption='[[7wid]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7wid]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WID FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DF:(6S,9aS)-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-N-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide'>9DF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wid OCA], [https://pdbe.org/7wid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wid RCSB], [https://www.ebi.ac.uk/pdbsum/7wid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wid ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A0D1I3W4_STAAU A0A0D1I3W4_STAAU] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.[HAMAP-Rule:MF_00444][RuleBase:RU000550] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus]] | |||
[[Category: Gan JH]] | |||
[[Category: Wei BY]] | |||
[[Category: Yang C-G]] | |||
Revision as of 23:07, 16 November 2022
Crystal structure of Staphylococcus aureus ClpP in complex with ZG180Crystal structure of Staphylococcus aureus ClpP in complex with ZG180
Structural highlights
FunctionA0A0D1I3W4_STAAU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.[HAMAP-Rule:MF_00444][RuleBase:RU000550] |
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