4i0c: Difference between revisions

<StructureSection load='4i0c' size='340' side='right'caption='[[4i0c]], [[Resolution|resolution]] 1.95&Aring;' scene=''>

<table><tr><td colspan='2'>[[4i0c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I0C FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0c OCA], [https://pdbe.org/4i0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i0c RCSB], [https://www.ebi.ac.uk/pdbsum/4i0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i0c ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[https://omim.org/entry/105200 105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref>  

[https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

*[[3D structures of non-human antibody|3D structures of non-human antibody]]

[[Category: Camelus dromedarius]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chan PH]]

[[Category: Chirgadze DY]]

[[Category: Christodoulou J]]

[[Category: De Genst E]]

[[Category: Dobson CM]]

[[Category: Dumoulin M]]

[[Category: Kumita JR]]

[[Category: Matagne A]]

[[Category: Menzer L]]

[[Category: Muyldermans S]]

[[Category: Pardon E]]

[[Category: Robinson CV]]

[[Category: Wyns L]]