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'''Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus''' | '''Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus''' | ||
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[[Category: Tsuchiya, D.]] | [[Category: Tsuchiya, D.]] | ||
[[Category: Yoshida, M.]] | [[Category: Yoshida, M.]] | ||
[[Category: | [[Category: Aaa domain fold]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:33:51 2008'' | |||
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Revision as of 20:33, 2 May 2008
Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus
OverviewOverview
FtsH is a cytoplasmic membrane-integrated, ATP-dependent metalloprotease, which processively degrades both cytoplasmic and membrane proteins in concert with unfolding. The FtsH protein is divided into the N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. We have determined the crystal structures of the Thermus thermophilus FtsH ATPase domain in the nucleotide-free and AMP-PNP- and ADP-bound states, in addition to the domain with the extra preceding segment. Combined with the mapping of the putative substrate binding region, these structures suggest that FtsH internally forms a hexameric ring structure, in which ATP binding could cause a conformational change to facilitate transport of substrates into the protease domain through the central pore.
About this StructureAbout this Structure
1IY0 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
ReferenceReference
Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8., Niwa H, Tsuchiya D, Makyio H, Yoshida M, Morikawa K, Structure. 2002 Oct;10(10):1415-23. PMID:12377127 Page seeded by OCA on Fri May 2 20:33:51 2008