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==Neisseria gonorrhoeae peptidyl-tRNA hydrolase complexed with an XChem hit.== | |||
<StructureSection load='8axp' size='340' side='right'caption='[[8axp]], [[Resolution|resolution]] 1.83Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8axp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AXP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O0J:N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide'>O0J</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8axp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8axp OCA], [https://pdbe.org/8axp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8axp RCSB], [https://www.ebi.ac.uk/pdbsum/8axp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8axp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PTH_NEIG2 PTH_NEIG2] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria. | |||
Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction.,Hassell-Hart S, Speranzini E, Srikwanjai S, Hossack E, Roe SM, Fearon D, Akinbosede D, Hare S, Spencer J Org Lett. 2022 Nov 4;24(43):7924-7927. doi: 10.1021/acs.orglett.2c02996. Epub, 2022 Oct 20. PMID:36265082<ref>PMID:36265082</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 8axp" style="background-color:#fffaf0;"></div> | ||
[[Category: Fearon | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Neisseria gonorrhoeae]] | |||
[[Category: Fearon D]] | |||
[[Category: Roe SM]] | |||
Revision as of 10:32, 9 November 2022
Neisseria gonorrhoeae peptidyl-tRNA hydrolase complexed with an XChem hit.Neisseria gonorrhoeae peptidyl-tRNA hydrolase complexed with an XChem hit.
Structural highlights
FunctionPTH_NEIG2 The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Publication Abstract from PubMedA library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria. Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction.,Hassell-Hart S, Speranzini E, Srikwanjai S, Hossack E, Roe SM, Fearon D, Akinbosede D, Hare S, Spencer J Org Lett. 2022 Nov 4;24(43):7924-7927. doi: 10.1021/acs.orglett.2c02996. Epub, 2022 Oct 20. PMID:36265082[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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