7ugp: Difference between revisions

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-'''Unreleased structure'''
-The entry 7ugp is ON HOLD  until Paper Publication
+==Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1==
+<StructureSection load='7ugp' size='340' side='right'caption='[[7ugp]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
-Authors: Dam, K.A., Bjorkman, P.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ugp]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UGP FirstGlance]. <br>
-Description: Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan-Class 1
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ugp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ugp OCA], [https://pdbe.org/7ugp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ugp RCSB], [https://www.ebi.ac.uk/pdbsum/7ugp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ugp ProSAT]</span></td></tr>
-[[Category: Dam, K.A]]
+</table>
-[[Category: Bjorkman, P.J]]
+== Function ==
+[https://www.uniprot.org/uniprot/Q2N0S5_9HIV1 Q2N0S5_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292][SAAS:SAAS00139820]  The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.[SAAS:SAAS00140087]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Human immunodeficiency virus 1]]
+[[Category: Large Structures]]
+[[Category: Bjorkman PJ]]
+[[Category: Dam KA]]