7try: Difference between revisions

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-'''Unreleased structure'''
-The entry 7try is ON HOLD  until Paper Publication
+==Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein==
+<StructureSection load='7try' size='340' side='right'caption='[[7try]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
-Authors: Zhao, L.-H., Lin, J., Mao, C., Zhou, X.E., Ji, S., Shen, D., Xiao, P., Melcher, K., Zhang, Y., Yu, X., Xu, H.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7try]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRY FirstGlance]. <br>
-Description: Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7try FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7try OCA], [https://pdbe.org/7try PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7try RCSB], [https://www.ebi.ac.uk/pdbsum/7try PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7try ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Zhang, Y]]
+== Function ==
-[[Category: Zhou, X.E]]
+[https://www.uniprot.org/uniprot/CRFR2_HUMAN CRFR2_HUMAN] G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
-[[Category: Xu, H.E]]
+__TOC__
-[[Category: Yu, X]]
+</StructureSection>
-[[Category: Zhao, L.-H]]
+[[Category: Homo sapiens]]
-[[Category: Lin, J]]
+[[Category: Large Structures]]
-[[Category: Melcher, K]]
+[[Category: Rattus norvegicus]]
-[[Category: Xiao, P]]
+[[Category: Synthetic construct]]
-[[Category: Shen, D]]
+[[Category: Ji S]]
-[[Category: Ji, S]]
+[[Category: Lin J]]
-[[Category: Mao, C]]
+[[Category: Mao C]]
+[[Category: Melcher K]]
+[[Category: Shen D]]
+[[Category: Xiao P]]
+[[Category: Xu HE]]
+[[Category: Yu X]]
+[[Category: Zhang Y]]
+[[Category: Zhao L-H]]
+[[Category: Zhou XE]]