1ixm: Difference between revisions
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{{STRUCTURE_1ixm| PDB=1ixm | SCENE= }} | |||
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'''CRYSTAL STRUCTURE OF SPOOB FROM BACILLUS SUBTILIS''' | '''CRYSTAL STRUCTURE OF SPOOB FROM BACILLUS SUBTILIS''' | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Varughese, K I.]] | [[Category: Varughese, K I.]] | ||
[[Category: | [[Category: Phosphotransferase]] | ||
[[Category: | [[Category: Regulatory protein]] | ||
[[Category: | [[Category: Sporulation response regulator]] | ||
[[Category: | [[Category: Two component system]] | ||
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Revision as of 20:33, 2 May 2008
CRYSTAL STRUCTURE OF SPOOB FROM BACILLUS SUBTILIS
OverviewOverview
A basis for understanding specificity of molecular recognition between phosphorelay proteins has been deduced from the 2.6 A structure of the Spo0B phosphotransferase of the phosphorelay regulating sporulation initiation. Spo0B consists of two domains: an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerize by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine protrudes. Docking studies show that both the monomers interact with a Spo0F molecule at the region surrounding the active site aspartate to position it for phosphotransfer. It is apparent that different surfaces of response regulators may be involved in recognition of the protein partners to which they are paired.
About this StructureAbout this Structure
1IXM is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
ReferenceReference
Formation of a novel four-helix bundle and molecular recognition sites by dimerization of a response regulator phosphotransferase., Varughese KI, Madhusudan, Zhou XZ, Whiteley JM, Hoch JA, Mol Cell. 1998 Oct;2(4):485-93. PMID:9809070 Page seeded by OCA on Fri May 2 20:33:01 2008