Glycolysis Enzymes: Difference between revisions

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'''Step 5: Triose Phosphate Isomerase'''
'''Step 5: Triose Phosphate Isomerase'''


The interconversion of two three-carbon phosphosugars is catalyzed by [[Christian_Krenk_Sandbox|triose phosphate isomerase]], also referred to as TIM.
[[Triose Phosphate Isomerase]] (TPI or TIM) is a ubiquitous dimeric enzyme with a molecular weight of ~54 kD (27 kD per subunit) which catalyzes the reversible interconversion of the triose phosphate isomers <scene name='Triose_Phosphate_Isomerase/Morph/1'>dihydroxyacetone phosphate (DHAP)</scene> and <scene name='Triose_Phosphate_Isomerase/Morph/2'>D-glyceraldehyde-3-phosphate (GAP)</scene>, an essential process in the glycolytic pathway. More simply, the enzyme catalyzes the <scene name='Triose_Phosphate_Isomerase/Morph/3'>isomerization of a ketose (DHAP) to an aldose (GAP)</scene>, also referred to as '''PGAL'''.
* [[Triose Phosphate Isomerase]]


'''The next five reactions are the "payoff" phase of glycolysis''', where energy in the forms of ATP and NADH is generated. All of the subsequent reactions happen twice (once for each of the two glyceraldehyde 3 phosphate molecules generated from glucose).  
'''The next five reactions are the "payoff" phase of glycolysis''', where energy in the forms of ATP and NADH is generated. All of the subsequent reactions happen twice (once for each of the two glyceraldehyde 3 phosphate molecules generated from glucose).  

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