C-reactive protein: Difference between revisions
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== Background == | == Background == | ||
'''C-Reactive Protein''' (CRP) is member of the pentraxin family which is characterised by its pentameric architecture and by its calcium-dependent binding of its ligands. | '''C-Reactive Protein''' (CRP) is member of the '''pentraxin''' family which is characterised by its pentameric architecture and by its calcium-dependent binding of its ligands. | ||
Throughout the medical field, the CRP has been used to clinically determine whether or not there is an infection, tissue injury, or an inflammatory response occurring within the body. Thus, CRP is a major acute-phase protein, in which its concentration can reach levels upwards of 10+mg/L <ref name=Evolution>Pathak A and Agrawal A (2019) Evolution of C-Reactive Protein. Front. Immunol. 10:943. doi: 10.3389</ref>. In comparison, normal CRP levels within the human body are referenced to be estimated at | Throughout the medical field, the CRP has been used to clinically determine whether or not there is an infection, tissue injury, or an inflammatory response occurring within the body. Thus, CRP is a major acute-phase protein, in which its concentration can reach levels upwards of 10+mg/L <ref name=Evolution>Pathak A and Agrawal A (2019) Evolution of C-Reactive Protein. Front. Immunol. 10:943. doi: 10.3389</ref>. In comparison, normal CRP levels within the human body are referenced to be estimated at | ||
0.8mg/L depending on the subject. In a pathophysiological sense, CRP has been researched to be a "significant predictor of future cardiac episodes" <ref name=Physiological>Boncler, M. “The Multiple Faces of C-Reactive Protein-Physiological and pathophysiological Implications in Cardiovascular Disease.” Journal MDPI, Nov. 2019</ref>. With that, CRP is determined to play a specific role in both physiological and pathophysiological aspects within the human body. | 0.8mg/L depending on the subject. In a pathophysiological sense, CRP has been researched to be a "significant predictor of future cardiac episodes" <ref name=Physiological>Boncler, M. “The Multiple Faces of C-Reactive Protein-Physiological and pathophysiological Implications in Cardiovascular Disease.” Journal MDPI, Nov. 2019</ref>. With that, CRP is determined to play a specific role in both physiological and pathophysiological aspects within the human body. | ||