Glycolysis Enzymes: Difference between revisions
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*[[Aldolase]] | *[[Aldolase]] | ||
[[Austin_Drake_Sandbox|Aldolase]] catalyzes the retro-aldol cleavage of fructose 1,6-bisphosphate into two three-carbon phosphosugars, dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. | [[Austin_Drake_Sandbox|Aldolase]] catalyzes the retro-aldol cleavage of <scene name='39/392339/Cv/8'>fructose 1,6-bisphosphate</scene> into two three-carbon phosphosugars, dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. | ||
The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation. Catalysis occurs first when the nucleophilic ε-amine group of Lys229 attacks the carbonyl carbon of the substrate (FBP) in its open-ring state, pushing an electron pair to the oxygen of the carbonyl. The oxygen is protonated and leaves as water as a protonated <scene name='Austin_Drake_Sandbox/Schiff_base/2'>Schiff base</scene> is produced (an imine resulting from a ketone and amine) with the open-ring form of FBP | The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation. Catalysis occurs first when the nucleophilic ε-amine group of Lys229 attacks the carbonyl carbon of the substrate (FBP) in its open-ring state, pushing an electron pair to the oxygen of the carbonyl. The oxygen is protonated and leaves as water as a protonated <scene name='Austin_Drake_Sandbox/Schiff_base/2'>Schiff base</scene> is produced (an imine resulting from a ketone and amine) with the open-ring form of FBP | ||