4hap: Difference between revisions
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<StructureSection load='4hap' size='340' side='right'caption='[[4hap]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='4hap' size='340' side='right'caption='[[4hap]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4hap]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4hap]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Limnoria_quadripunctata Limnoria quadripunctata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HAP FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand= | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=PRD_900005:beta-cellobiose'>PRD_900005</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hap OCA], [https://pdbe.org/4hap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hap RCSB], [https://www.ebi.ac.uk/pdbsum/4hap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hap ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GH7B_LIMQU GH7B_LIMQU] Exocellobiohydrolase (CBH) that catalyzes the hydrolysis of 1,4-beta-D-glucosidic bonds in cellulose to release the disaccharide cellobiose (PubMed:23733951). The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with endoglucanases (EGs), which cut internal beta-1,4-glucosidic bonds in cellulose to reduce the polymerization degree of the substrate and create new chain ends for exocellobiohydrolases (CBHs). The CBHs release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units (Probable).<ref>PMID:23733951</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Limnoria quadripunctata]] | [[Category: Limnoria quadripunctata]] | ||
[[Category: Bruce | [[Category: Bruce NC]] | ||
[[Category: Cragg | [[Category: Cragg SM]] | ||
[[Category: Guille | [[Category: Guille MJ]] | ||
[[Category: Kern | [[Category: Kern M]] | ||
[[Category: Martin | [[Category: Martin RNA]] | ||
[[Category: McGeehan | [[Category: McGeehan JE]] | ||
[[Category: McQueen-Mason | [[Category: McQueen-Mason SJ]] | ||
[[Category: Schnorr | [[Category: Schnorr KM]] | ||
[[Category: Streeter | [[Category: Streeter SD]] | ||