4h4b: Difference between revisions
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==Human cytosolic 5'-nucleotidase II in complex with Anthraquinone-2,6- disulfonic acid== | ==Human cytosolic 5'-nucleotidase II in complex with Anthraquinone-2,6- disulfonic acid== | ||
<StructureSection load='4h4b' size='340' side='right' caption='[[4h4b]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='4h4b' size='340' side='right'caption='[[4h4b]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4h4b]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4h4b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H4B FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=11H:9,10-DIOXO-9,10-DIHYDROANTHRACENE-2,6-DISULFONIC+ACID'>11H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=11H:9,10-DIOXO-9,10-DIHYDROANTHRACENE-2,6-DISULFONIC+ACID'>11H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4b OCA], [https://pdbe.org/4h4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h4b RCSB], [https://www.ebi.ac.uk/pdbsum/4h4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4b ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Aghajari | [[Category: Aghajari N]] | ||
[[Category: Rhimi | [[Category: Rhimi M]] | ||