4h2h: Difference between revisions
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==Crystal structure of an enolase (mandalate racemase subgroup, target EFI-502101) from Pelagibaca bermudensis htcc2601, with bound mg and l-4-hydroxyproline betaine (betonicine)== | ==Crystal structure of an enolase (mandalate racemase subgroup, target EFI-502101) from Pelagibaca bermudensis htcc2601, with bound mg and l-4-hydroxyproline betaine (betonicine)== | ||
<StructureSection load='4h2h' size='340' side='right' caption='[[4h2h]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='4h2h' size='340' side='right'caption='[[4h2h]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4h2h]] is a 8 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4h2h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Salipiger_bermudensis_HTCC2601 Salipiger bermudensis HTCC2601]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H2H FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XW:(2S,4R)-4-HYDROXY-1,1-DIMETHYLPYRROLIDINIUM-2-CARBOXYLATE'>0XW</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XW:(2S,4R)-4-HYDROXY-1,1-DIMETHYLPYRROLIDINIUM-2-CARBOXYLATE'>0XW</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2h OCA], [https://pdbe.org/4h2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h2h RCSB], [https://www.ebi.ac.uk/pdbsum/4h2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2h ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HPBD_SALBH HPBD_SALBH] Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. To a lesser extent, can also catalyze the racemization of L-proline betaine.<ref>PMID:24056934</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4h2h" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4h2h" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Mandelate racemase/muconate lactonizing enzyme 3D structures|Mandelate racemase/muconate lactonizing enzyme 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Salipiger bermudensis HTCC2601]] | ||
[[Category: | [[Category: Almo SC]] | ||
[[Category: Gerlt | [[Category: Gerlt JA]] | ||
[[Category: Imker | [[Category: Imker HJ]] | ||
[[Category: Morisco | [[Category: Morisco LL]] | ||
[[Category: Sojitra | [[Category: Sojitra S]] | ||
[[Category: Vetting | [[Category: Vetting MW]] | ||
[[Category: Wasserman | [[Category: Wasserman SR]] | ||