1hac: Difference between revisions
New page: left|200px<br /> <applet load="1hac" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hac, resolution 2.60Å" /> '''CROSSLINKED HAEMOGL... |
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==Overview== | ==Overview== | ||
Hemoglobin has been a long-standing paradigm for understanding protein, allostery. Here, the x-ray structures of two chemically crosslinked, fully, liganded hemoglobins, alpha2beta82CA82beta and alpha2beta82ND82beta, are, described at 2.3 A and 2.6 A resolution, respectively. Strikingly, these, crosslinked hemoglobins assume intermediate conformations that lie between, those of R and the controversial liganded hemoglobin state R2 rather than, between R and T. Thus, these structures support only a T left and right, arrow R left and right arrow R2 allosteric pathway and underscore the, physiological importance of the R2 conformation. | Hemoglobin has been a long-standing paradigm for understanding protein, allostery. Here, the x-ray structures of two chemically crosslinked, fully, liganded hemoglobins, alpha2beta82CA82beta and alpha2beta82ND82beta, are, described at 2.3 A and 2.6 A resolution, respectively. Strikingly, these, crosslinked hemoglobins assume intermediate conformations that lie between, those of R and the controversial liganded hemoglobin state R2 rather than, between R and T. Thus, these structures support only a T left and right, arrow R left and right arrow R2 allosteric pathway and underscore the, physiological importance of the R2 conformation. | ||
==Disease== | |||
Known diseases associated with this structure: Erythremias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Erythremias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], HPFH, deletion type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Heinz body anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Heinz body anemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Heinz body anemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Hemoglobin H disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Hypochromic microcytic anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Methemoglobinemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Methemoglobinemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Sickle cell anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Thalassemia, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Thalassemia-beta, dominant inclusion-body OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Thalassemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Thalassemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]] | |||
==About this Structure== | ==About this Structure== | ||
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[[Category: respiratory protein]] | [[Category: respiratory protein]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:14:48 2007'' | ||
Revision as of 18:08, 12 November 2007
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CROSSLINKED HAEMOGLOBIN
OverviewOverview
Hemoglobin has been a long-standing paradigm for understanding protein, allostery. Here, the x-ray structures of two chemically crosslinked, fully, liganded hemoglobins, alpha2beta82CA82beta and alpha2beta82ND82beta, are, described at 2.3 A and 2.6 A resolution, respectively. Strikingly, these, crosslinked hemoglobins assume intermediate conformations that lie between, those of R and the controversial liganded hemoglobin state R2 rather than, between R and T. Thus, these structures support only a T left and right, arrow R left and right arrow R2 allosteric pathway and underscore the, physiological importance of the R2 conformation.
DiseaseDisease
Known diseases associated with this structure: Erythremias, alpha- OMIM:[141800], Erythremias, beta- OMIM:[141900], Erythrocytosis OMIM:[141850], HPFH, deletion type OMIM:[141900], Heinz body anemia OMIM:[141850], Heinz body anemias, alpha- OMIM:[141800], Heinz body anemias, beta- OMIM:[141900], Hemoglobin H disease OMIM:[141850], Hypochromic microcytic anemia OMIM:[141850], Methemoglobinemias, alpha- OMIM:[141800], Methemoglobinemias, beta- OMIM:[141900], Sickle cell anemia OMIM:[141900], Thalassemia, alpha- OMIM:[141850], Thalassemia-beta, dominant inclusion-body OMIM:[141900], Thalassemias, alpha- OMIM:[141800], Thalassemias, beta- OMIM:[141900]
About this StructureAbout this Structure
1HAC is a Protein complex structure of sequences from Homo sapiens with HEM, CMO and NDD as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Allosteric intermediates indicate R2 is the liganded hemoglobin end state., Schumacher MA, Zheleznova EE, Poundstone KS, Kluger R, Jones RT, Brennan RG, Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7841-4. PMID:9223274
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