1isn: Difference between revisions

Revision as of 20:21, 2 May 2008

Crystal structure of merlin FERM domain

OverviewOverview

Neurofibromatosis type 2 (NF2) is a dominantly inherited disease associated with the central nervous system. The NF2 gene product merlin is a tumor suppressor, and its mutation or inactivation causes this disease. We report here the crystal structure of the merlin FERM domain containing a 22-residue alpha-helical segment. The structure reveals that the merlin FERM domain consists of three subdomains displaying notable features of the electrostatic surface potentials, although the overall surface potentials similar to those of ezrin/radixin/moesin (ERM) proteins indicate electrostatic membrane association. The structure also is consistent with inactivation mechanisms caused by the pathogenic mutations associated with NF2.

About this StructureAbout this Structure

1ISN is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain., Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Tsukita S, Hakoshima T, J Biol Chem. 2002 Mar 22;277(12):10332-6. Epub 2001 Dec 27. PMID:11756419 Page seeded by OCA on Fri May 2 20:21:58 2008

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OCA

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 '''Crystal structure of merlin FERM domain'''
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-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:24:05 2008''